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Symbol
Name
ID

Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
MGI:95810

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Spasticity

Ventriculomegaly

Frontal cortical atrophy

Hypoplasia of the corpus callosum

Cerebellar vermis hypoplasia

Retrocerebellar cyst

Myoclonus

Limb tremor

Babinski sign

Interictal epileptiform activity

Reduced eye contact

Delayed speech and language development

Severe expressive language delay

Atypical behavior

Autistic behavior

Autism

Aggressive behavior

Self-injurious behavior

Self-mutilation

Intellectual disability

Intellectual disability, mild

Intellectual disability, moderate

Intellectual disability, severe

Sleep abnormality

Sleep-wake cycle disturbance

Hyperreflexia

Hyporeflexia

Global developmental delay

Motor delay

Specific learning disability

Seizure

Bilateral tonic-clonic seizure

Focal tonic seizure

Status epilepticus

Pain insensitivity

Disease(s) Associated with GRIA3

syndromic X-linked intellectual disability 94

Mouse Phenotypes		nervous system phenotype	decreased susceptibility to pharmacologically induced seizures	abnormal long-term potentiation	abnormal miniature excitatory postsynaptic currents
Availability	Mouse Genotype	nervous system phenotype		abnormal long-term potentiation	abnormal miniature excitatory postsynaptic currents
	Gria3^tm1Rlh/Gria3^tm1Rlh	*
	Gria3^tm2Rlh/Gria3^tm2Rlh	*
	Gria3^em1Wthg/Y
	Gria3^tm1Dgen/Y
	Gria3^tm1Zpj/Y

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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